If by “isolated” you mean “the location is far from other locations” then you would need to :
Loop through each location point and find its mean distance from all other points. That is if point ‘A’ is surrounded by ‘B’, ‘C’ and ‘D’ you would calculated distance of A from all the three and then take the “mean” of them.
Then you would need to compare the mean distances of all points and find the point with maximum mean distance. This point will be your most isolated location.
Python has a very useful library geopy that lets you calculate distance between two locations based on their latitude and longitude.
pip install geopy
Distance between two cities:
from geopy.distance import great_circle
bangalore = (12.9716, 77.5946)
delhi = (28.7041, 77.1025)
#distance in miles
Hope this helps,